Education

Dorleta Otaegui holds her Bachelor's Degree in Pharmacy in 2004 from the University of the Basque Country (UPV/EHU), with a solid foundation in pharmacology, chemistry, and biology applied to the pharmaceutical industry.
She then pursued her Ph.D. in Organic Chemistry at the same institution, completing it in 2009. Her doctoral research combined computational chemistry techniques to predict the molecular interactions of inhibitors with histone deacetylases (HDACs), followed by the synthesis of these compounds in the laboratory. The newly synthesized compounds were then subjected to biological activity assays to evaluate their effectiveness in inhibiting HDAC enzymes. Additionally, the pharmacokinetic profiles of the most promising inhibitors were studied to assess their potential as therapeutic agents.
In 2015, she obtained a Certification in Experimental Animal Techniques in compliance with ethical and legal standards for biomedical research.

Research

Dorleta Otaegui has extensive knowledge and experience in the synthesis and characterization of bioactive chemical compounds, particularly in the areas of drug development, mass spectrometry, and preclinical development. Her research background includes the design of new compounds with potential anticancer activity, as well as the optimization of biotechnological processes for viral vector production.
She has gained experience in a variety of analytical techniques, including:
• Mass Spectrometry (ESI-TOF, MALDI-TOF) for structural characterization of new chemical entities
• ICP-MS and UPLC-ESI-MS for quantitative analysis of biological and material samples
• Dynamic Light Scattering (DLS) for particle size analysis
• HPLC-MS for compound quantification and purity determination
• AKTA Protein Purification systems
Throughout her career, she has been deeply involved in preclinical research, particularly in oncology, and has coordinated studies on pharmacokinetics, formulation, and stability of new compounds. She has also been responsible for developing analytical methods to monitor the progress of drug development, from synthesis to preclinical testing.

Publications